Random model rho Outcome BMI

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Review: Pharmacotherapy forweight loss in adults with type 2 diabetes mellitus

Comparison: 23 Drug therapy versus placebo for Sibutramine (FT: 1-13, fixed model; 14-26, random model. rho=0.75) Outcome: 04 BMI

Study

Treatment Control Weighted Mean Difference (Fixed) Weight Weighted Mean Difference (Fixed)

Treatment Control Weighted Mean Difference (Fixed) Weight Weighted Mean Difference (Fixed)

Finer 2000

43

-0.90 (!.!!)

40

-0.!0 (!.08)

27.2

-0.80 [ -!.27,

-0.33 ]

Fujioka 2000

60

-1.30 (!.20)

6!

-0.20 (0.90)

42.2

-!.!0 [ -!.48,

-0.72 ]

Gokcel 200!

29

-3.92 (2.9!)

25

0.36 (!.05)

4.7

-4.28 [ -5.42,

-3.!4 ]

McNulty 2003

49

-2.90 (4.90)

46

-0.30 (4.75)

!.6

-2.60 [ -4.54,

-0.66 ]

Redmon 2003

27

-2.60 (2.60)

27

-0.30 (!.56)

4.6

-2.30 [ -3.44,

-!.!6 ]

Serrano-Rios 2002

53

-!.90 (!.46)

57

-0.60 (!.5!)

a

!9.6

-!.30 -!.86,

-0.74 ]

Test for heterogeneity chi-square=36.47 df=5 p=

Test for overall effect z=l0.25 p<0.0000l

256 =<0.000! I

? —86.3%

«

!00.0

-!.29 [ -!.53,

-!.04 ]

-10.0 -5.0 0 5.0 10.0 Favours treatment Favours control

Review: Pharmacotherapy forweight loss in adults with type 2 diabetes mellitus

Comparison: 23 Drug therapy versus placebo for Sibutramine (FT: 1-13, fixed model;l4-26, random model. rho=0.75) Outcome: 05 Waist circumference

Study Treatment ControlWeighted Mean Difference (Fixed) Weight Weighted Mean Difference (Fixed)

Fujioka 2000

60

-3.40

(6.20)

61

-2.00 (4.60)

27.9

-1.40

-3.35, 0.55 ]

Gokcel 2001

29

-8.04

18.47)

25

0.92 (2.45)

2.3

-8.96

-15.75

-2.17]

McNulty 2003

49

-6.60

4.90)

46

0.20 (4.07)

32.4

-6.80

-8.61,

-4.99 ]

Serrano-Rios 2002

53

-5.10

(5.82)

57

-2.60 (4.53)

27.6

-2.50

-4.46,

-0.54 ]

Tankova 2003

53

-8.40

7.32)

42

-1.90 (8.63)

9.9

-6.50

-9.77,

-3.23 ]

Test for heterogeneity chi-square=22.55 df=4 p=

Test for overall effect z=7.87 p<0.0000l

231 0.0002 I??

=82.3%

100.0

-4.13

-5.16,

3.10]

-10.0 -5.0 0 5.0 10.0 Favours treatment Favours control

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