Analysis Comparison Drug therapy versus placebo for Sibutramine FT fixed model random model rho Outcome Waist circumference

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Review: Pharmacotherapy forweight loss in adults with type 2 diabetes mellitus

Comparison: 23 Drug therapy versus placebo for Sibutramine (FT: l-l3, fixed model; l4-26, random model. rho=0.75) Outcome: l8 Waist circumference

Study

Treatment Control Weighted Mean Difference (Random) Weight Weighted Mean Difference (Random)

Treatment Control Weighted Mean Difference (Random) Weight Weighted Mean Difference (Random)

Fujioka 2000

60

-3.40

(6.20)

6l

-2.00 (4.60)

23.5

-1.40

-3.35, 0.55 ]

Gokcel 2001

29

-8.04

18.47)

25

0.92 (2.45)

9.9

-8.96 [

-15.75

-2.17]

McNulty 2003

49

-6.60

(4.90)

46

0.20 (4.07)

23.9

-6.80 [

-8.61,

-4.99 ]

Serrano-Rios 2002

53

-5.10

(5.82)

57

-2.60 (4.53)

23.5

-2.50 [

-4.46,

-0.54 ]

Tankova 2003

53

-8.40

7.32)

42

-1.90 (8.63)

-■-

19.2

-6.50 [

-9.77,

-3.23 ]

Total (95% CI) 244 Test for heterogeneity chi-square Test for overalleffect z=3.4l p=

=22.55 df=4 p 0.0006

231 0.0002 I??

=82.3%

100.0

-4.68 [

-7.36,

1.99 ]

-10.0 -5.0 0 5.0 10.0 Favours treatment Favours control

Review: Pharmacotherapy for weight loss in adults with type 2 diabetes mellitus

Comparison: 23 Drug therapy versus placebo for Sibutramine (FT: 1-13, fixed model;l4-26, random model. rho=0.75) Outcome: 19 GHb

Study

Treatment Control Weighted Mean Difference (Random) Weight Weighted Mean Difference (Random)

Finer 2000

43

-0.30 (!.98)

40

0.00 (!.75)

-i

!3.2

-0.30 [-!.!0

0.50 ]

Fujioka 2000

60

0.!7 (0.99)

6!

0.27 (0.94)

!4.9

-0.!0 [-0.44

0.24 ]

Gokcel 200!

29

-2.73 (0.54)

25

-0.53 (0.50)

!5!

-2.20 [ -2.48

-!.92 ]

McNulty 2003

49

-0.32 (!.6!)

46

-0.22 (!.63)

-i

!3.9

-0.!0 [-0.75

0.55 ]

Redmon 2003

27

-0.60 (!.56)

27

0.00 (!.04)

!3.6

-0.60 [-!.3!

0.!! ]

Serrano-Rios 2002

53

-0.78 (!.3!)

57

-0.68 (!.74)

4

!4.2

-0.!0 [-0.67

0.47 ]

Tankova 2003

53

-0.33 (0.6!)

42

-0.05 (0.75)

!5!

-0.28 [ -0.56

0.00 ]

Total (95% CI) 3!4 Test for heterogeneity chi-square Test for overalleffect z—!.35 p=

= !38.79 df—6 0.2

!00.0

-0.54 [-!.32

0.24 ]

-10.0 -5.0 0 5.0 10.0 Favours treatment Favours control

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