Analysis Comparison Drug therapy versus placebo for Sibutramine FT fixed model random model rho Outcome Waist circumference

Review: Pharmacotherapy forweight loss in adults with type 2 diabetes mellitus

Comparison: 23 Drug therapy versus placebo for Sibutramine (FT: l-l3, fixed model; l4-26, random model. rho=0.75) Outcome: l8 Waist circumference

Study

Treatment Control Weighted Mean Difference (Random) Weight Weighted Mean Difference (Random)

Treatment Control Weighted Mean Difference (Random) Weight Weighted Mean Difference (Random)

Fujioka 2000

60

-3.40

(6.20)

6l

-2.00 (4.60)

23.5

-1.40

-3.35, 0.55 ]

Gokcel 2001

29

-8.04

18.47)

25

0.92 (2.45)

9.9

-8.96 [

-15.75

-2.17]

McNulty 2003

49

-6.60

(4.90)

46

0.20 (4.07)

23.9

-6.80 [

-8.61,

-4.99 ]

Serrano-Rios 2002

53

-5.10

(5.82)

57

-2.60 (4.53)

23.5

-2.50 [

-4.46,

-0.54 ]

Tankova 2003

53

-8.40

7.32)

42

-1.90 (8.63)

-■-

19.2

-6.50 [

-9.77,

-3.23 ]

Total (95% CI) 244 Test for heterogeneity chi-square Test for overalleffect z=3.4l p=

=22.55 df=4 p 0.0006

231 0.0002 I??

=82.3%

100.0

-4.68 [

-7.36,

1.99 ]

-10.0 -5.0 0 5.0 10.0 Favours treatment Favours control

Review: Pharmacotherapy for weight loss in adults with type 2 diabetes mellitus

Comparison: 23 Drug therapy versus placebo for Sibutramine (FT: 1-13, fixed model;l4-26, random model. rho=0.75) Outcome: 19 GHb

Study

Treatment Control Weighted Mean Difference (Random) Weight Weighted Mean Difference (Random)

Finer 2000

43

-0.30 (!.98)

40

0.00 (!.75)

-i

!3.2

-0.30 [-!.!0

0.50 ]

Fujioka 2000

60

0.!7 (0.99)

6!

0.27 (0.94)

!4.9

-0.!0 [-0.44

0.24 ]

Gokcel 200!

29

-2.73 (0.54)

25

-0.53 (0.50)

!5!

-2.20 [ -2.48

-!.92 ]

McNulty 2003

49

-0.32 (!.6!)

46

-0.22 (!.63)

-i

!3.9

-0.!0 [-0.75

0.55 ]

Redmon 2003

27

-0.60 (!.56)

27

0.00 (!.04)

!3.6

-0.60 [-!.3!

0.!! ]

Serrano-Rios 2002

53

-0.78 (!.3!)

57

-0.68 (!.74)

4

!4.2

-0.!0 [-0.67

0.47 ]

Tankova 2003

53

-0.33 (0.6!)

42

-0.05 (0.75)

!5!

-0.28 [ -0.56

0.00 ]

Total (95% CI) 3!4 Test for heterogeneity chi-square Test for overalleffect z—!.35 p=

= !38.79 df—6 0.2

!00.0

-0.54 [-!.32

0.24 ]

-10.0 -5.0 0 5.0 10.0 Favours treatment Favours control

Dynamic Six Pack Abs

Dynamic Six Pack Abs

Reasonable care has been taken to ensure that the information presented in this book is accurate. However, the reader should understand that the information provided does not constitute legal, medical or professional advice of any kind.

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