Analysis Comparison Drug therapy versus placebo for Fluoxetine FT fixed model random model wks rho Outcome Triglycerides

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Review: Pharmacotherapy for weight loss in adults with type 2 diabetes mellitus

Comparison: 07 Drug therapy versus placebo for Fluoxetine (FT: l-6, fixed model;7-l2, random model;24-26 wks. rho=0.75) Outcome: 06 Triglycerides

Study

Treatment N Mean(SD)

Control N Mean(SD)

Weighted Mean Difference (Fixed) Weight 95% CI (%)

Weighted Mean Difference (Fixed) 95% CI

O'Kane l 994

Test for heterogeneity: not applicable

Test for overall effect z=0.36 p=0.7

100.0 100.0

-10.0 -5.0 Favours treatment

5.0 10.0 Favours control

Review: Pharmacotherapy forweight loss in adults with type 2 diabetes mellitus

Comparison: 07 Drug therapy versus placebo for Fluoxetine (FT: 1-6, fixed model;7-l2, random model;24-26 wks. rho=0.75) Outcome: 07 Weight (kg) random

Study

Treatment N Mean(SD)

ControlWeighted Mean Difference (Random) Weight Mean(SD) 95% CI (%)

Weighted Mean Difference (Random) 95% CI

39.3

-3.90

-6.65, -1.15 ]

6.0

-7.40[

-14.78, -0.02 ]

43.6

-6.50

-9.09, -3.91 ]

11.1

-2.40[

-7.79, 2.99 ]

100.0

-5.08[

-6.90, -3.26 ]

Connolly 1995 Gray 1992 O'Kane 1994 Zelissen 1992 Total (95% CI)

11 16

8 10

-3.90 (4.45) -9.30 (9.60) -6.30 (2.22) -2.45 (7.68)

Test for heterogeneity chi-square=3.l9 df=3 p=0.36 I?? =6.0 Test for overall effect z=5.46 p<0.0000l

-10.0 -5.0 0 5.0 10.0 Favours treatment Favours control

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