The Hla Complex

The short arm of human chromosome 6 (6p21) accommodates an approximate 3.5-megabase genetic segment containing a group of immune response genes termed the major histocompatibility complex (MHC) (see Fig. 1). The principal genes located within the MHC code for human leukocyte antigens, or HLA, two molecular classes of cell surface glycoproteins differing in structure, function, and tissue distribution (see Table 5 and Fig. 1).

The class I HLA molecule exists as a heterodimer, consisting of a polymorphic 44-kDa MHC-encoded a-chain or heavy chain in noncovalent association with p2-microglobulin, a 12-kDa protein encoded by a nonpolymorphic gene on chromosome 15. The class I molecule is anchored to the cell membrane only by the heavy chain.

Table 4

Phenotypes/Functions Controlled by Idd Loci

Table 4

Phenotypes/Functions Controlled by Idd Loci

Locus or

Was this article helpful?

0 0
Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

Get My Free Ebook


Post a comment