Genetics of Type Diabetes

The Big Diabetes Lie

Curing Diabetes Permanently

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Massimo Pietropaolo, MD and Massimo Trucco, MD

Contents

Introduction What Are the Genes The HLA Complex HLA Genes and T1DM

HLA Complex and Mechanisms of Susceptibility to or

Protection from T1DM T-Cell Receptor Characteristics and Susceptibility to T1DM

The Insulin Gene Region (IDDM2) Biological Significance of the VNTR Region The Search for Novel Non-MHC Susceptibility Genes A Pattern Is Arising: Colocalization of Autoimmune

Disease Loci Concluding Remarks References

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