Normal Insulin Physiology

Hour Basal Insulin Secretion Rate

The healthy pancreas secretes insulin into the portal system in response to daily variations in nutrient intake and energy expenditure. Polonsky et al. carefully characterized the normal 24-h insulin secretion of healthy subjects 4 . They found that daily insulin secretion was pulsatile and could be divided into two components a constant basal secretion rate and marked increases in insulin secretion following meals Fig. 1 . The basal component of insulin release, which comprises approximately...

Disseminated Granuloma Annulare

Disseminated Granuloma Annulare Images

Granuloma annulare GA is an idiopathic disorder that occurs in both children and adults. The individual lesions are pink to skin-colored papules and they often coalesce to form rings and arcs, hence the term annulare. In the classic form of the disease, lesions are found predominantly on the distal extremities. One theory advanced to explain the distribution of GA is that it represents an unusual granulomatous reaction to trauma or arthropod bites. Occasionally, a patient will have generalized...