Glyco Mark

In contrast to the traditional hemoglobin A1c test, changes occur rapidly in the GlycoMark test. Like the hemoglobin A1c, it's a blood test, but a better result in the GlycoMark test is a higher value, not a lower one.

The GlycoMark test takes advantage of the fact that the compound 1,5-anhydroglucitol (or 1,5 AG) is normally found in healthy people. It's filtered by the kidneys and reabsorbed into the blood. However, when a lot of glucose is present in the urine, reabsorption is blocked, and the level of 1,5 AG in the blood falls. As glucose is reduced by treatment, blood levels of 1,5 AG rise.

Table 7-2 shows the values for GlycoMark found in people without and with diabetes.

Table 7-2

GlycoMark Test Results

GlycoMark (ug/ml)

Diabetes Control

Glucose (mg/dl)

14.0 or higher

Normal (no diabetes)

Under 160



Under 200


Moderate control



Poor control

Less than 2

Very poor control

Large changes in GlycoMark results occur in just two weeks, so you can use the test to detect early improvement or deterioration in your child's glucose control. In addition, the glucose after eating (called postprandial glucose) seems to have a big effect on the result of the GlycoMark test. Many specialists believe that the postprandial glucose has a greater effect on diabetic complications than glucose at other times. I expect the GlycoMark test to find a more prominent role in following diabetes care in years to come.

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