Mw

Lipoproteins

Metabolic functions apo A-1 28,016 HDL, chylomicrons apo A-II 17,414 HDL, chylomicrons apo A-IV 46,465 HDL, chylomicrons apo B-48 264,000 chylomicrons apo B-100 514,000 VLDL, IDL, LDL

apo C-I 6,630 chylomicrons,

VLDL, IDL, HDL apo C-II 8,900 chylomicrons,

VLDL, IDL, HDL apo C-III 8,800 chylomicrons,

VLDL, IDL, HDL

apo E 34,145 chylomicrons,

VLDL, IDL, HDL

800,000

Structural component of HDL;

LCAT activator Unknown

Unknown; possibly facilitates transfer of apos between HDL and chylomicrons Necessary for assembly and secretion of chylomicrons from the small intestine Necessary for the assembly and secretion of VLDL from the liver; structural protein of VLDL, IDL and LDL; ligand for the LDL receptor May inhibit hepatic uptake of chylomicrons VLDL remnants Activator of lipoprotein lipase

Inhibitor of lipoprotein lipase; inhibits hepatic uptake of chy-lomicron and VLDL remnants Ligand for binding of several li-poproteins to the LDL receptor, LRP, and proteoglycans Composed of LDL apo B linked covalently to apo(a); function unknown, but is an independent predictor of coronary artery disease named because it is the full-length protein made from the messenger RNA) is synthesized in the liver, as is required for the secretion of liver-derived very- -o low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), and |

low-density lipoproteins (LDL). Apo B48 is a truncated form of apo B100 (it is S

made from the first half of the messenger RNA for apo B100) that is made in -g the small intestine and is required for secretion of chylomicrons after ingestion of a meal. Apo A-I is the major structural protein in high-density lipoproteins Ji

(HDL) and plays a key role in reverse cholesterol transport. Other apolipoproteins J

will be discussed in the context of their roles in lipoprotein metabolism. a

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