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Data are mean ± standard deviation.

Data are mean ± standard deviation.

From the perspective of cardiovascular disease, a more sensible way to classify diabetes mellitus is to define two variants. One in which there is no significant insulin resistance and the other in which insulin resistance is a dominant pathophysiological abnormality (6-8). The rationale for this classification is that insulin resistance is associated with a cluster of metabolic abnormalities (Table 3), all of which are significant risk factors for cardiovascular disease (9,10), while diabetes mellitus without insulin resistance is only associated with increased risk factors for cardiovascular disease after the diabetes has progressed for many years, and the increased risk factors are usually secondary to the complications of poor control (11,12) or treatment.

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