Causes Of Insulin Resistance

Insulin resistance may be caused by rare genetic defects that alter insulin binding to its cellular receptors or cause defects in receptor or postreceptor signal trans-duction (1). Recently, defects in the nuclear receptor, PPARy, have also been linked to syndromes of severe insulin resistance (2). In addition, some endocrine-metabolic syndromes, such as Cushing's syndrome, acromegaly, and polycystic ovary syndrome, are associated with insulin resistance because of the hormonal imbalances associated with these conditions. However, in the most common forms of insulin resistance, single gene defects have not been identified and the development of insulin resistance represents a complex interaction among a poorly understood array of predisposing genetic factors and acquired environmental factors that modify insulin sensitivity. Among the latter, the most prominent are obesity (particularly intra-abdominal obesity), physical inactivity, and increasing age. It is also now well documented that metabolic abnormalities such as chronic elevations of plasma glucose or free fatty acids (FFA), as well as increases in tissue triglycerides, can lead to insulin resistance (3,4). This has led to the concepts of glucotoxicity and lipotoxicity, both of which are reversible with improved metabolic status. Although the mechanism by which chronic elevation of glucose results in insulin resistance is not fully understood, it is most likely related to changes in glucose transporter number and function as well as to changes in the activity of the PI-3'-K signaling pathway in insulin-sensitive tissues. Chronic elevation of FFAs, on the other hand, has multiple metabolic effects that both inhibit glucose utilization in peripheral tissues and increase hepatic glucose production through enhanced gluconeogenesis. In addition, intra-cellular triglyceride accumulation is associated with decreased insulin action in insulin-sensitive tissues. Yet another mechanism by which increased body fat accumulation may cause insulin resistance is through increased production of adipose tissue hormones such as TNF-a (5), which has an inhibitory effect on insulin action. Finally, various medications may cause insulin resistance. These include treatment with hormones such as glucocorticoids, growth hormone, pro-gestational agents, high doses of androgens and anabolic steroids, or commonly used agents such as beta-adrenergic agonists or nicotinic acid.


When insulin resistance is present, fasting and postprandial blood glucose concentrations are maintained in the normal range by a compensatory increase in insulin secretion and the development of hyperinsulinemia. As long as the pancre- Ji atic beta cell is able to compensate adequately, glucose tolerance remains normal. J

However, if beta-cell function is inadequate, impaired glucose tolerance (IGT)

& u may develop. This is characterized by the maintenance of a normal fasting blood glucose concentration but a value that is intermediate between normal and the diabetic range 2 h after a 75-g oral glucose load. With further impairment of beta-cell function, both fasting and postprandial blood glucose concentrations increase and overt diabetes mellitus develops. This sequence of events has been demonstrated in prospective studies of insulin resistance and beta-cell function in several populations, including studies of Pima Indians who have either progressed sequentially from normal glucose tolerance to IGT and then to diabetes or who have maintained normal glucose tolerance (NGT) over several years (6). In those who progressed to diabetes, there was only a modest increase in insulin resistance over time, whereas a marked decrease in beta-cell function occurred. In contrast, those who did not progress maintained adequate beta-cell function to compensate for their worsening insulin resistance.

It is now clear from the United Kingdom Prospective Diabetes Study (UKPDS) that once type 2 diabetes is established, it becomes progressively more difficult to control over time, often requiring combinations of oral antidiabetic agents and/or insulin therapy (7,8). This is due largely to a progressive loss of beta-cell function, which is insufficient to overcome the underlying insulin resistance. Thus, insulin resistance is a fundamental underpinning of an entire spectrum of glucose intolerance from NGT with compensatory hyperinsulinemia, to IGT or full-blown type 2 diabetes with progressive loss of pancreatic beta-cell function.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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