What technical problems exist in the transplantation of the pancreatic islets

Most research centres report that for every recipient, islets from two cadaveric pancreases are needed. Islet transplantation from only one donor has, however, been successful as well. The medicines that are usually given to a patient in an intensive care unit before he or she becomes an organ donor influence the quality of the islets. The process, from the moment of removal of the pancreas until the beginning of the islet isolation, should not exceed 18 hours, since the islets are destroyed quickly. Moreover, an islet transplantation centre has large expenses, since it employs very specialized personnel continuously on standby so that they can receive a cadaveric pancreas and process it to isolate the islets. During the isolation, around 30-50 percent of the cadaveric pancreatic islets are destroyed. It should be noted that every detail of the technique has not yet been determined, and it is not the same at all centres applying it. This entails different results and is one of the reasons why the number of islets received from a pancreas is not yet ideal.

The transplantation itself includes very few risks. The most common undesirable side effect is the thrombosis of a branch of the portal vein or bleeding, which however can be controlled. As is the case for the transplantation of the whole pancreas, immunosuppression is needed, with the same risks as involved in transplantation of the pancreas (risk of infections, small percentage of lymphomas).

0 0

Post a comment