What is the particular therapeutic characteristic of meglitinides

Meglitinides have a rapid onset and rapid end to their hypoglycaemic action. This characteristic renders them useful for the control of postprandial glucose levels and for the avoidance of hypoglycaemias several hours after a meal. Repaglinide and nateglinide tablets are recommended to be taken immediately before a meal. If a meal is skipped, the medicine should not be received. These characteristics are considered as advantages of meglitinides over sulfonylureas.

The main undesirable effect of meglitinides is hypoglycaemia, but this does occur less frequently than the hypoglycaemia caused by sulfonylureas. The increase in the body weight caused by meglitinides is also smaller than that of sulfonylureas.

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