This is the United Kingdom Prospective Diabetes Study (UKPDS) from 1998. This study concerned the roughly decennial follow-up of individuals diagnosed with Type 2 DM. A comparison was performed between conventional (with diet only) and intensive treatment of DM with pills (glibenclamide (glyburide), chlorpropamide, glipizide, metformin and acarbose) and/or insulin, with regard to the prevention of chronic diabetic complications (HbAlc lower by 0.9 percent in the intensive treatment group). Only information received by patients who were treated with glibenclamide, chlorpropamide and metformin were statistically significant enough to allow conclusions to be reached regarding blood sugar control.
Diabetes in Clinical Practice: Questions and Answers from Case Studies. Nicholas Katsilambros et al. © 2006 John Wiley & Sons, Ltd. ISBN: 0-470-03522-6
This study showed that the intensive treatment of DM with glibencla-mide, chlorpropamide, metformin or insulin can considerably decrease the morbidity of the chronic complications of DM, compared to conventional treatment, without indicating any particular advantage of any of these antidiabetic substances.
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