How does the risk of hypoglycaemia increase in individuals receiving aspirin or other medicines

Aspirin occupies the binding sites of sulfonylureas to the serum albumin. The problem usually concerns large doses of aspirin. With the same mechanism, fibrates and trimethoprim increase the action of sulfonylureas. Allopurinol and probenecid inhibit the excretion of sulfonylureas from the kidneys. Anticoagulants, alcohol and H2-blockers prevent their metabolism in a competitive way, while the alcohol also exerts a distinct hypoglycaemic action. Beta-blockers inhibit the action of the counter-regulatory hormones for the hypoglycaemia.

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