The typical picture consists of the sudden installation of heaviness or even pain, as a rule, mild, in the foot. Sometimes acute Charcot arthropathy can present itself after an infection of the foot, intervention for any reason in the ipsilateral or contralateral foot, and a few cases have been reported after interventions of lower extremity revascularization. Physical examination reveals the presence of serious degree of peripheral neuropathy, with normal peripheral pulses. The majority of patients have increased temperature, redness and oedema in the involved region. An invariable finding is the existence of at least 2°C temperature difference between the affected and the healthy foot. Moreover, this temperature difference constitutes a criterion of response to the therapeutic regimen. Erythrocyte sedimentation rate and CRP may be slightly elevated. The number of white blood cells is normal.
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