How do sulfonylureas act

Sulfonylureas are bound to a part of the b-cell cytoplasmic membrane potassium channel, called the sulfonylurea receptor (SUR, see Figure 27.1). This binding causes inhibition of the exit of potassium ions from the b-cell and a change of the cell's resting potential. This results in the opening of special calcium channels of the cytoplasmic

Sulfonylurea Mechanism
Figure 27.1. Mechanism with which glucose and sulfonylureas cause insulin secretion from the ß-cell. (Reprinted from Textbook of Diabetes, 3rd edn., J. Pickup & G. Williams, Copyright 2003, with permission from Blackwell Science Ltd.)

membrane, the entry of calcium ions inside the cell and the stimulation of insulin secretion. This is the way in which the response of the b-cell to glucose and other insulin-secreting stimuli (amino-acids, etc.) is ultimately performed. It is obvious that sulfonylureas act only when the capacity of the b-cell to produce insulin is intact.

Was this article helpful?

0 0
Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

Get My Free Ebook


  • Tuija Valle
    Can sulfonylureas cause neurapathy?
    6 years ago
  • faramir
    How do sulfonylureas act on the body?
    6 years ago

Post a comment