How do sulfonylureas act

Sulfonylureas are bound to a part of the b-cell cytoplasmic membrane potassium channel, called the sulfonylurea receptor (SUR, see Figure 27.1). This binding causes inhibition of the exit of potassium ions from the b-cell and a change of the cell's resting potential. This results in the opening of special calcium channels of the cytoplasmic

Sulfonylurea Mechanism
Figure 27.1. Mechanism with which glucose and sulfonylureas cause insulin secretion from the ß-cell. (Reprinted from Textbook of Diabetes, 3rd edn., J. Pickup & G. Williams, Copyright 2003, with permission from Blackwell Science Ltd.)

membrane, the entry of calcium ions inside the cell and the stimulation of insulin secretion. This is the way in which the response of the b-cell to glucose and other insulin-secreting stimuli (amino-acids, etc.) is ultimately performed. It is obvious that sulfonylureas act only when the capacity of the b-cell to produce insulin is intact.

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Responses

  • Tuija Valle
    Can sulfonylureas cause neurapathy?
    5 years ago
  • faramir
    How do sulfonylureas act on the body?
    5 years ago

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