Insulin Resistance Syndrome

The Big Diabetes Lie

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Reaven, at his Banting Lecture in 1988 (3), first proposed a widespread role for insulin resistance in common diseases such as coronary heart disease, Type 2 diabetes, obesity and hypertension. He proposed an insulin resistance syndrome (IRS) (or Syndrome X) as a unifying theory for a cluster of adverse metabolic changes (Table 9.1). Each of these changes have been independently shown to be related to a risk of cardiovascular disease. Insulin resistance is also a strong marker for the risk of developing Type 2 diabetes and therefore a

Table 9.1 Metabolic and related disorders associated with the insulin resistance syndrome

Glucose metabolism

Hyperinsulinaemia

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