References

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2. Nave, B. T., Haigh, R. J., Hayward, A. C., Siddle, K., and Shepherd, P. R. (1996) Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes. Biochem. J. 318(Pt. 1), 55-60.

3. Modan-Moses, D., Janicot, M., McLenithan, J. C., Lane, M. D., and Casella, S. J. (1998) Expression and function of insulin/insulin-like growth factor I hybrid receptors during differentiation of 3T3-L1 preadipocytes. Biochem. J. 333(Pt. 3), 825-831.

4. Funaki, M., Katagiri, H., Kanda, A., Anai, M., Nawano, M., Ogihara, T., et al. (1999) p85/p110-Type phosphatidylinositol kinase phosphorylates not only the D-3, but also the D-4 position of the inositol ring. J. Biol. Chem. 274(31), 22019-22024.

5. Sbrissa, D., Ikonomov, O. C., and Shisheva, A. (1999) PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin. J Biol. Chem. 274(31), 21589-21597.

6. Gagnon, A., Dods, P., Roustan-Delatour, N., Chen, C. S., and Sorisky, A. (2001) Phosphatidylinositol-3,4,5-trisphosphate is required for insulin-like growth factor 1-mediated survival of 3T3-L1 preadipocytes. Endocrinology 142(1), 205-212.

7. Ko, K. W., Avramoglu, R. K., McLeod, R. S., Vukmirica, J., and Yao, Z. (2001) The insulin-stimulated cell surface presentation of low density lipoprotein receptor-related protein in 3T3-L1 adipocytes is sensitive to phosphatidylinositide 3-kinase inhibition. Biochemistry 40(3), 752-759.

8. Sbrissa, D., Ikonomov, O., and Shisheva, A. (2001) Selective insulin-induced activation of class I(A) phosphoinositide 3- kinase in PIKfyve immune complexes from 3T3-L1 adipocytes. Mol. Cell. Endocrinol. 181(1-2), 35-46.

9. Stack, J. H. and Emr, S. D. (1994) Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidyli-nositol-specific PI 3-kinase activities. J. Biol. Chem. 269(50), 31,552-31,562.

10. Hama, H., Takemoto, J. Y., and DeWald, D. B. (2000) Analysis of phosphoinositides in protein trafficking. Methods 20(4), 465-473.

11. Stack, J. H., DeWald, D. B., Takegawa, K., and Emr, S. D. (1995) Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast. J. Cell. Biol. 129(2), 321-334.

12. Serunian, L.A., Auger, K.R., and Cantley, L.C. (1991) Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation. Methods Enzymol. 198, 78-87

13. Nasuhoglu, C., Feng, S., Mao, J., Yamamoto, M., Yin, H. L., Earnest, S., et al. (2002) Nonradioactive analysis of phosphatidylinositides and other anionic phos-pholipids by anion-exchange high-performance liquid chromatography with suppressed conductivity detection. Anal. Biochem. 301(2), 243-254.

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