MRI has been used to assess involvement of the spinal cord in neuropathy. In an exploratory study, Eaton et al. (2001) used MRI of the cord and demonstrated that patients with DPN had a lower cross-sectional cord area than healthy control subjects in the cervical and thoracic regions, leading them to suggest that DPN is not simply a disease of the peripheral nerves. However, progression or regression of this abnormality has not been evaluated in prospective studies and, therefore, the potential for its use as an endpoint in clinical trials of human DPN is not established.
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