Insulin stimulated whole body glucose metabolism

During euglycaemic hyperinsulinaemia, skeletal muscle is primarily responsible for the insulin dependent increase of whole body glucose metabolism (Figure 4.4 and 4.6A) DeFronzo etal. 1985). The contribution of the liver to whole body glucose metabolism is small under these conditions. However, splanchnic glucose uptake and thus the contribution of the liver to whole body glucose metabolism increases under hyperglycaemic hyperin-sulinaemic conditions (Basu et al. 2004; Krssak et al. 2004). Insulin stimulated whole body glucose metabolism depends on two major metabolic pathways: glucose oxidation and nonox-idative glucose metabolism. Nonoxidative glucose metabolism is primarily represented by glycogen synthesis, and skeletal muscle is the tissue accounting for the majority of insulin stimulated glycogen synthesis (Shulman etal. 1990). In insulin resistant states, lower rates of skeletal muscle glycogen synthesis are responsible for the reduction of insulin stimulated whole body glucose metabolism (Figure 4.6B) (Shulman etal. 1990; Roden etal. 1996b; DeFronzo 1988).

Healthy

Type 2 Diabetes mellitus

Healthy

Type 2 Diabetes mellitus

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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