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Figure 6.1 A) glucose concentrations (means and mean fitted values) collected from 8 am to 6 pm in patients with type 2 diabetes and in control subjects, who were prev'ously fasted for 12-14 h; B) rates of endogenous glucose production (Ra) calculated using non-steady state methods and a simultaneously infused tracer. Reproduced with permission from Radziuk J, Pye A. (2001) Production and metabolic clearance of glucose under basal conditions in type II (non-insulin dependent) diabetes. Diabetologia 44 983-991, Springer.

night in these fasting patients, peaking in the early morning and declining through the day to reach levels near those of the previous afternoon (Figure 6.2).

This was reflected in the underlying glucose production, which followed the same pattern, anticipating that in glycaemia. Again, the MCR did not change appreciably throughout this period. EGP in type 2 diabetes is seen to never be in steady state, displaying rather

Glucose

Glucose

200 400 600 800 1000 1200 Time of tracer infusion (min)

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