Index

acanthosis nigricans 77, 104 acromegaly 2, 18 acute complications of DM 63-7 Addison's disease 18 adenovirus 12

adhesive capsulitis, shoulder 78 alcohol 33, 63

alprostadil (prostaglandin Ej) 76, 90, 91 American Diabetes Association (ADA) diagnostic criteria 1-2, 14 etiologic classification 6 exercise guidelines 34 GDM criteria 112,113 HbAjc target 38

hyperlipidemia screening recommendations 110 Working Group on the Prevention of Diabetes recommendations 14 amputation, lower-limb 73, 74 amylin 11, 117

angiotensin II receptor antagonist 73 angiotensin-converting enzyme (ACE) inhibitor 70,

73-4 apomorphine 76 arthropathy

Charcot's 74, 93, 94 cheiroarthropathy 77-8, 106 atheromatous lesions 73 atorvastatin 109, 110

B lymphocytes 10 bacterial infection, skin 105 Bacteroides spp. 74 balanitis 104 Banting, Frederick 4 becaplermin 95

bendrofluazide 74 Best, Charles H. 4 beta-blockers 74 bezafibrate 110 blood glucose 36-7

monitoring systems 37, 56, 117 plasma profile

'glucose excursions' 55 insulin injections 49, 50 non-diabetic 49 stable control 55 self-monitoring technique 53 subcutaneously implanted continuous monitoring system 37, 56, 117 bovine serum albumin 10 'brittle' diabetics 38 bullae 77, 103

calcium-channel blockers 74 calorie restriction 34 candidiasis 104

carbohydrates, dietary management of type 1 DM 33 cardiovascular disease 73

recurrent coronary heart disease (CHD) events 73 carpal tunnel syndrome 72 P-cells, pancreatic autoimmune destruction 10 dysfunction 10-12 monogenetic defects 2, 9 stem cell generated 117 viral infection 9-10 Charcot's arthropathy 74, 93, 94 cheiroarthropathy 77-8, 106 children and adolescents childhood obesity 21

childhood type 2 diabetes 2

continuous subcutaneous insulin infusion (CSII) 60 emotional problems 59 hypoglycemia 59 insulin requirements 59-60 macrosomic babies 108, 111 puberty 60 treatment 59-60 cholesterol 33, 109

Cholesterol and Recurrent Events Trial (CARE) 109 chronic complications of DM 69-108 cirrhosis 76-7 classification of DM 2-3, 6

Collaborative Atorvastatin Diabetes Study (CARDS) 109

coma, hyperosmolar non-ketoacidotic 67

continuous ambulatory peritoneal dialysis (CAPD) 71

continuous subcutaneous insulin infusion (CSII) 60

Coxsackie B virus 10, 12

creatinine level 70-1,112

Cushing's syndrome 2,17

cystic fibrosis 2, 28

cytomegalovirus 10, 12

Da Qing study, China 14 depression 115 dermopathy 77, 102

Diabetes Control and Complications Trial (DCCT),

USA 35, 37, 63, 69 diabetes mellitus (DM), definition 1 Diabetes Prevention Program, USA 14 diabetes specialist nurses (DSNs) 37, 61 Diabetes UK, GDM recommendations 112 'diabetic foods' 33 diagnostic criteria of DM 1-2, 7 dialysis 71 diazoxide 2 dietary advice 56, 57 DIGAMI study 73

dipeptidyl peptidase-IV (DPP-IV) inhibitor 117 Dose Adjustment for Normal Eating (DAFNE) program 37-8

Down's syndrome 2, 12 doxazosin 74 driving licence, UK 115 drug treatment dose range, distribution and half-life 58 type 2 diabetes 39-40 Dupuytren's contracture 78, 107 dyslipidemia 109-10

endocannabinoid system 117-18 entrapment syndrome 72, 87 environmental factors for children and adolescents 59-60 viral infection 9, 10, 12, 30 Epstein-Barr virus 10 erectile dysfunction (ED) causes 75 hypogonadism 76 treatment 76, 89 vacuum pump system 76, 88 vasoactive drug injection 76, 90 transurethral application 76, 90 eruptive xanthomata 77, 105, 106 Escherichia coli 44

European Diabetes Project Group, HbAjc target 38 European Nicotinamide Diabetes Intervention Trial

(ENDIT) 13 exenatide 117 exercise 34

and insulin sensitivity 34 eye disorders

DIDMOAD syndrome 80 laser photocoagulation 84 maculopathy 82 normal fundus 80 ophthalmology referral 85 retinal detachment 82 retinopathy 69-70, 80-5 thromboneovascular glaucoma 84 triamcinolone therapy 82 vitreous hemorrhage 85 ezetimibe 110

fasting plasma glucose (FGP) concentration 1

fat intake 33, 34

fenofibrate 110

fibrates 110

fiber, dietary 33

fibrocalculous pancreatopathy 2 Finnish Diabetes Prevention Study 14, 71 foot disorders burn injuries 88 callus 74

Charcot's arthropathy 74, 93, 94 deep infection 74, 93 digital arterial calcification 75, 97, 98 gangrene 96, 97 osteomyelitis 74, 75, 94

treatment 75, 95 ulcer 74, 92, 95 weight-bearing reduction 95 future developments

ß-cells, stem cell generated 117 continuous glucose monitoring 117 inhaled insulin delivery 117, 119 insulin pumps 117 islet cell transplantation 117 oral insulin delivery 117 pancreatic transplantation 117 pharmaceutical products 117-18

gastric neurostimulator (GES) system 88 gemfibrozil 77, 109, 110 genes DBQ1 9 glucokinase 12 INS (insulin gene) 9 genetic loci

7p (glucokinase) 12 11p5.5 (IDDM2) 9 geographic variation of DM 1, 3 gestational diabetes mellitus (GDM) 2, 14, 112 ADA recommendations 112,113 Cesarian section rates 112 Diabetes UK recommendations 112 HAPO study 113

O'Sullivan-Mahan criteria (USA) 2 WHO criteria 2, 112, 113 see also pregnancy glitazones 14,39-40,41,77 glomerulopathy 91

glucagon-like peptide-1 (GLP-1) 11, 117

glucocorticoids 2

glucose metabolism, brain 66 tolerance, impaired 2, 3, 11, 14 see also blood glucose glucose-dependent insulinotropic polypeptide (GIP)

11, 117 a-glucosidase inhibitors 39 glucotoxicity 11

glutamic acid decarboxylase (GAD) antibodies 10 gluten 10

glycemic control 38, 70 granuloma annulare 102

health-care costs 1

Heart Outcomes Prevention Evaluation Study (HOPE

study) 74 hemochromatosis 2, 19, 29 hemoglobin (HbA1c) 34

in pregnancy 111 targets 38 hepatic nuclear factors (HFNs) 2, 11-12 hepatic portal vein, isolated islet administration 119 high-density lipoprotein (HDL) 109 human leukocyte antigen (HLA) 9

HLA antigens 9 hydroxymethylglutaryl-coenzyme A reductase inhibitor

109-10 hyperbaric oxygen 75 hyperglycemia 11 in pregnancy 111 sugars 33 in surgery 61 symptoms 1

Hyperglycemic Adverse Pregnancy Outcome (HAPO)

study 113 hyperinsulinemia 11,77 hyperlipidemia 71, 109-10 hyperosmolar non-ketoacidotic coma 67 hypertension 70-1, 73-4 hypertriglyceridemia 109 hypoglycemia 33-7, 63, 65 brain glucose metabolism 66 children and adolescents 59 hypoglycemia-induced cardiac dysrhythmia 63 neonatal 111 in surgery 61 symptoms 63 hypoinsulinemia 34 fetal 111

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