Box Genetic susceptibility to type diabetes mellitus

General population: 0.3% Relatives: 2-50% Twins

patibility complex allelic variability on T1D risk may, for example, be explained by differences in the presentation of islet cell antigens, either by promoting antiself reactivity or by failing to impart regulated immune responses. Most patients who have T1D carry the HLA-DR3 or -DR4 class II antigens, with 30% being DR3/DR4 heterozygous. In white persons, the DR3/DR4 genotype confers the highest T1D risk, followed by DR4 and DR3 homozygosity, respectively [13]. Conversely, the class II allele, DQB 1*0602, in linkage disequilibrium with DR2, is associated with protection from the development of T1D and is found in less than 1% of patients with T1D (Table 2).

Table 1

Type 1 diabetes mellitus susceptibility loci

Table 1

Type 1 diabetes mellitus susceptibility loci





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