Cardiovascular Disease in Women with Diabetes

Sonia Gajula, Ashwini Reddy, L. Romayne Kurukulasuriya, Camila Manrique, Guido Lastra, and James R. Sowers

Contents

Introduction

Impact and Burden of Diabetes on Cardiovascular

Disease in Women Platelet and Coagulation Abnormalities in Diabetes Endothelial Dysfunction Screening and Diagnosis of Cad Treatment of Cvd in Women with Diabetes Summary References

Abstract

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in women in the USA. Women with diabetes are at a greater risk of CVD than men with diabetes. In this chapter we review the various mechanisms by which hyperglycemia potentiates this increased CVD risk, including coagulation abnormalities as well as endothelial dysfunction. Where applicable, sex-specific differences in these mechanisms are highlighted. Finally, the impact and burden of diabetes on CVD as well as screening for CVD in women are discussed.

Key words: Diabetes mellitus; Coagulation abnormalities; Hyperglycemia; Endothelial dysfunction; Insulin resistance; Oxidative stress; Metabolic syndrome; Cardiovascular disease; Sex differences.

From: Diabetes in Women: Pathophysiology and Therapy Edited by: A. Tsatsoulis et al. (eds.), DOI 10.1007/978-1-60327-250-6_3 © Humana Press, a part of Springer Science+Business Media, LLC 2009

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