Observational Studies Of Blood Pressure Lowering Therapy And The Prevention Of Stroke

Early observational studies raised the possibility that blood pressure lowering treatment, particularly with diuretics, might be associated with a worsening of prognosis among hypertensive individuals with diabetes [9,10]. More recently, based on the results of case-control studies, cohort studies and some relatively small randomised trials, there had been concern that the use of calcium antagonists rather than other antihypertensive agents may result in greater cardiovascular morbidity and mortality among diabetics [11-13]. Such observational data, however, are prone to confounding [14] and in this instance they have not been confirmed by the results of clinical trials.

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