Hyperglycemia And Proteinuria

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The onset of microalbuminuria in patients with type 2 diabetes may be transient and related to increases in glomerular filtration rate in association with hyperglycemia. Albuminuria has been shown to decrease with decreases in glucose levels in patients with newly diagnosed type 1 or type 2 diabetes [4547]. However, other researchers reported no decline in albumin excretion with control of hyperglycemia in patients with newly diagnosed type 2 diabetes [48]. The United Kingdom Prospective Diabetes Study showed that the risk for microalbuminuria was proportional to the level and duration of glucose elevation [49]. Furthermore, in type 1 diabetes the level of glycosylated hemoglobin correlates with glomerular disease [50]. In type 1 diabetic patients in the Diabetes Control and Complications Trial, rigorous control of blood glucose reduced the development of microalbuminuria and the progression from microalbuminuria to overt proteinuria [51]. The United Kingdom Prospective Diabetes Study in type 2 diabetic subjects showed that well-controlled blood glucose reduced the risk of diabetic nephropathy and other microvascular, but not macrovascular, sequelae [49]. Glycemic control must be optimized to prevent or retard the development of diabetic nephropathy.

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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