Genetics Of Hspg Abnormalities In Diabetes

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The existence of genetic polymorphisms in the N-deacetylase/N-sulfotransferase enzymes has thus far not been reported. Animal experiments performed by Kofoed-Enevoldsen et al [40-42] support the influence of genetic factors in modulating the vulnerability of the N-deacetylase/N-sulfotransferase enzyme towards diabetes-induced inhibition, as evident from studies involving different rat strains.

Recently, a BamHI restriction fragment length polymorphism in the perlecan gene was found to be associated with diabetic nephropathy in Caucasian insulin-dependent diabetes mellitus [48]. However, in type 2 Japanese diabetic patients the BamHI HSPG2 genotype and allele frequencies were not significantly different between the patients with nephropathy and the patients without nephropathy [49]. No data are available on the role of variants of agrin in diabetes complications.

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