Blood Pressure And Stroke Risk Among Diabetics

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Among the general population, usual levels of both systolic and diastolic blood pressure are positively and continuously associated with the risk of stroke and there appears to be no threshold of blood pressure below, which this relationship fails to hold [6,7]. Overviews of prospective observational studies have shown that each 10mmHg lower level of usual systolic blood pressure and each 5mmHg lower level of usual diastolic blood pressure is associated with approximately 35-40% lower risk of fatal and non-fatal stroke [6,7]. While the

Mogensen CE (ed.) THE KIDNEY AND HYPERTENSION IN DIABETES MELLITUS. Copyright© 2004 by Martin Dunitz, a member of the Taylor & Francis Group, plc. All rights reserved.

majority of participants in the epidemiological studies included in these overviews did not have diabetes, where data do exist, the association between blood pressure and the risk of stroke appears to be similar among diabetics to that among non-diabetics (Figure 1). Similar continuous relationships have been observed among diabetic participants in clinical trials [8].

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+ Diabetics ^ Non-diabetics

120 130 140 150 160

Usual systolic blood pressure (mmHg)

Figure 1. Association between usual systolic blood pressure and fatal stroke among individuals with and without diabetes.

Previously unpublished data from the first round of overview analyses of the Asia Pacific Cohort Studies Collaboration demonstrating similar associations between usual systolic blood pressure and the risk of fatal stroke among participants with and without diabetes (Personal Communication: Woodward M, 2003). Data are included from 24 prospective cohort studies that involved 4,873 participants with diabetes (72 fatal strokes) and 156,341 without (1,082 fatal strokes) [3].

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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