Animal Studies Of Renal Autoregulation In Diabetes Mellitus

The Big Diabetes Lie

Natural Diabetes Treatment Book

Get Instant Access

Several studies in streptozotocin diabetic rats and dogs have suggested that hyperglycaemia induces impaired autoregulation of RBF and GFR [52,58-60]. Changes in vasoactive hormone activities have been suggested to contribute to impaired renal autoregulation [61,62]. Furthermore, a rise in growth hormones in diabetic patients induces glomerular structural changes, which may change the regulation of GFR [63]. Diabetic autoregulation impairment develops over time [58,59], but impaired afferent arteriolar contraction during increased renal arterial pressure can occur in the early course of experimental diabetes [52,64]. Furthermore diabetes has been shown to impair TGF response [60,65]. Other investigators have however shown preserved [66] or even enhanced autoregulatory ability (shift of the autoregulation range to the left (fig. 1)) in rats with short time diabetes [67].

Was this article helpful?

0 0
Diabetes Sustenance

Diabetes Sustenance

Get All The Support And Guidance You Need To Be A Success At Dealing With Diabetes The Healthy Way. This Book Is One Of The Most Valuable Resources In The World When It Comes To Learning How Nutritional Supplements Can Control Sugar Levels.

Get My Free Ebook


Post a comment