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Reductions in HbA1c and corresponding reductions in microvascular and macrovascular complications described in major studies of people with type 1 and type 2 diabetes.

Figure 5.2 How 10 obese men and 10 lean men fare on the journey through life (Joslin, 1941).

Reductions in HbA1c and corresponding reductions in microvascular and macrovascular complications described in major studies of people with type 1 and type 2 diabetes.

Diabetes related mortality is increasing...

% change in age-adjusted mortality rate since 1979

% change in age-adjusted mortality rate since 1979

Figure 5.3 Whilst overall cardiovascular mortality is declining, its rate in the population with diabetes is increasing (based on US data). Reproduced from Sobel etal. Circulation 2003;107; 636-642

Microvascular Endpoints

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