Antihypertensive Agents

Recently, losartan and olmesartan, antihypertensive drugs known to act through angiotensin receptor inhibition, have been shown to decrease AGE formation (191). Hydralazine, another antihypertensive agent whose effect does not involve the renin-angiotensin system, has AGE-inhibitory effects similar to those of low-dose olmesartan (192). The renoprotective effects shown by these drugs suggest that they derive not only from the drugs effect on lowering blood pressure and blocking angiotensin but also from reduced AGE formation (193).

conclusions

An increasing body of evidence indicates that AGEs play a significant role in the pathogenesis of diabetic complications. Further studies, however, are still needed to elucidate the exact role of AGEs in this area. More importantly, as these studies progress, new approaches to therapy to reduce the life-threatening impact of these complications would develop. Dietary restriction of AGE intake appears as a novel and important intervention tool that deserves further development.

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