Diabetes and Its Relationship to Pancreatic Carcinoma

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The link between pancreatic cancer (PC) and diabetes mellitus is recognized, however controversy still exists because no criteria have been established for the efficient selection of a high-risk group among patients with diabetes mellitus. Regulation of endocrine cell mass is thought to have a central role in the pathogenesis of both diseases. The processes that operate during pancreatic adaptation to a changing hormonal milieu are important in pancreatic carcinogenesis. There is evidence that somatostatin and its receptors are fundamental regulators of endocrine cell mass and are involved in islet tumorigenesis [57].

A hospital-based case-control study revealed that cigarette smoking, family history of PC, heavy alcohol consumption (>60 ml ethanol/day) and diabetes mellitus are significant risk factors for PC. The significant synergy between these risk factors suggests a common pathway for carcinogenesis of the pancreas [58].

Because of the poorly understood temporal association between diabetes melli-tus and PC, a research group at the Mayo Clinic College of Medicine, Rochester, Minn., USA [59] compared temporal patterns in diabetes prevalence in PC and controls. Diabetes has a high prevalence in PC and frequently is now onset. Longstanding type 2 diabetes increases the risk of PC by approximately 50%. Furthermore, there seems to be a positive association between obesity and PC [60]. However, as the mechanisms for these associations remain speculative, further studies are deserved. Above all, there is an urgent need for the identification of specific biomarkers for PC-induced diabetes, which may allow screening for PC in new-onset diabetes.

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Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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