Pioglitazone and Macrovascular Disease

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A recent study [31] investigated the effects of intensive glycemic control on macrovascular disease. It was a prospective, randomized controlled trial involving over 5,000 type 2 diabetics with preexisting macrovascular complications. They were randomized to receive either 45-mg pioglitazone or placebo for approximately 2.5 years. Pioglitazone was shown to reduce the risk of all cause mortality, non-fatal myocardial infarction (excluding silent myocardial infarction), and stroke by approximately 16% as compared with placebo. There was, however, an increase in the rate of heart failure in the pioglitazone group (11%) versus placebo (8%). The study concluded that pioglitazone improved cardiovascular outcomes in type 2 diabetics with high cardiovascular risk profiles.

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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