Given the high level of recent interest in developing drugs for weight loss, it seems likely that newer, perhaps more effective agents will eventually become available. Agents currently under evaluation include new lipase inhibitors, ¡-receptor agonists, cholecystokinin receptor agonists, cannabinoid receptor-1 receptor antagonists, the anticonvulsant topiramate, and leptin analogues. Diabetes management would be transformed if a safe, highly effective weight loss agent became available, but this seems unlikely in the near future.
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