Thiazolidendiones Glitazones

Thiazolidenediones (TZD), including pioglitazone and rosiglitazone, work by enhancing insulin-mediated glucose uptake; however, their effects are pleiotropic and their mechanisms of action are incompletely understood. Weight gain (5 to 10 kg) is common with TZD therapy. Fluid retention and edema formation can occur and TZD may precipitate clinical deterioration in patients with congestive heart failure. This adverse effect appears to occur more frequently when TZD are used in combination with insulin. Since hypoglycemia does not occur with monotherapy, TZD therapy may be particularly useful for patients who are at high risk for hypoglycemia.

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