Summary And Conclusions

The IRS is a major public health problem contributing to considerable morbidity related to diabetes and CVD. Consensus-based definition of the syndrome should lead to greater recognition in clinical practice. Several components of the syndrome are routinely evaluated in practice and frequently duster in patients.

Our understanding of the pathophysiological processes that are involved has improved considerably. This has resulted in the development of new treatments directly targeting insulin resistance that has significant benefits on several aspects of the syndrome. Current research is focused on improving our understanding of the etiology of the syndrome and finding new therapeutic interventions.

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