Risk For Development Of New Diabetes In Relation To Antihypertensive Drug Therapy

Because hypertension is often associated in large populations with impaired glucose tolerance, insulin resistance, and obesity, many patients with hypertension develop diabetes even when treated with placebo. Since in most diabetic patients combination therapy with two, or even three antihypertensive agents is likely to be required, the choice of which antihypertensive class should be given seems to be less problematic. When it comes to nondiabetic hypertensive patients, it seems to be more crucial. A meta-analysis of hypertension trials (91) involving about 116,000 patients, two-thirds of whom did not have diabetes at baseline, found an overall 25% reduction by RAS inhibition (27% for ACEi and 23% for ARB) in new-onset diabetes compared with other antihypertensive classes or placebo (91). Table 5 shows the

Effect of antihypertensive drug treatment on systolic and diastolic blood pressure in diabetic hypertensive patients of 10 trials

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