Peripheral Glucose Metabolism

Most (23,26,28,29,33-35), but not all studies (25,27,32,36) using the hyperinsulinemic-eugly-cemic clamp technique have shown a metformin-induced increase in insulin-stimulated glucose disposal in patients with type 2 diabetes varying from ~15% up to ~40% (Fig. 5) (30). Since muscle represents a major site of insulin-mediated glucose uptake (21,37), metformin must, either directly or via indirect mechanisms, have an insulin-like or insulin-sensitizing

Insulin resistance

Insulin resistance

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