It is thought that by eliminating the discomfort of finger-stick sampling, patients would SMBG more frequently. To be clinically useful, non-invasive glucose monitoring systems would have to be small, light weight, portable, safe and accurate. A variety of optical methods have been devised to measure glucose in blood, interstitial fluid (ISF) and eye fluid (15,16). The prototype devices require sophisticated optics and electronics for stability and high signal-to-noise. Unfortunately, there continues to be great variability in the optical signal when attempting to couple the light source and detector to the sample tissue. Complex signal processing and analytical techniques are required to extract the glucose information from the optical spectra. Recent technologies that are promising involve shinning a near-infrared light through the tongue (transmission spectroscopy) (15) and measuring the change in light polarization across the anterior chamber of the eye (optical rotation) (16).
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