Mutations In Hnf Mody Mody And Mody

Besides MODY2 other forms of MODY are caused by mutations in transcription factors of the HNF family that regulate gene expression of genes involved in the development and the maintenance of the pancreatic P-cell, i.e., (HNF)-1a (MODY3), HNF-1P (MODY5) and HNF-4a (MODY1).

Investigations of tissue-specific gene regulation in the liver resulted in the identification of the transcription factors HNF-1a and HNF-1P members of the basic-helix-loop-helix leucine

MODY: Lessons from Monogenetic Diabetes Forms TABLE 1 Molecular Genetics and Clinical Phenotypes In MODY

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