Mild Infections

Mild infections with limited cellulitis can generally be treated with oral antibiotics on an outpatient basis. Several antibiotics have been shown to be effective in clinical trials including cephalexin, clindamycin, ciprofloxacin. ofloxacin, levofloxacin, clindamycin, pexiganan, and linezolid. However, no single drug or combination of agents appears to be better than others. If MRSA is grown and there are no local or systemic signs of infection, topical mupirocin 2% ointment (if sensitive) may be used. If MRSA is grown and accompanied by local signs of infection, oral therapy with two of the following should be considered: sodium fusidate, rifampicin, trimethoprim and doxycycline, according to sensitivities, together with topical mupirocin 2% ointment.

Antibiotics should be consistent with local antibiotic policies and initially, commonly used first line antibiotics should be prescribed and new broad spectrum antibiotics reserved for later use for resistant organisms.

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