Insulin Resistance

It is a common assumption that all women with PCOS are insulin resistant, although this can be demonstrated only in about 70% of them with available tests (64-66), the main reason being that no generally accepted method for the quantification of insulin resistance exists (67,68). Clinically, in PCOS as well as other patients suspected of suffering from insulin resistance, the standard 2-h OGTT measuring both insulin and glucose yields the highest amount of information for a reasonable cost and risk, providing an assessment of both the degrees of hyperinsulinemia and glucose tolerance (69). In addition to obesity and family history of diabetes, ethnicity adversely affects the prevalence of insulin resistance, and generally minority populations with PCOS tend to be more insulin-resistant than Caucasians (33).

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