Info

30 min

3-4 h

Inactive metabolites

<10%

90% via feces

aCmax, maximum serum concentration. b r1/2, half-life.

aCmax, maximum serum concentration. b r1/2, half-life.

requiring lower doses of 30 to 120 mg, instead of 80 to 320 mg with the old twice daily formulation (13).

Repaglinide and nateglinide are administered immediately before meals 2 to 4 times daily. Repaglinide is available in doses of 0.5 to 2 mg/meal and patients should be started with the lowest dose. Nateglinide is usually given in the dose of 120 mg/meal, although a 60 mg tablet is available (14-19).

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