Info

Source: From Ref. 16.

Source: From Ref. 16.

concentrated in the brush border of the small intestine. Miglitol is unchanged, absorbed and excreted dose-dependently by the kidneys. Only 3% to 5% of voglibose is absorbed, and it is almost completely excreted via the feces. After oral administration, about 90% unchanged drug remains. By extrapolation, the most striking differences between AGIs in clinical use are with respect to absorption. Neither acarbose nor voglibose are absorbed in their active form, whereas miglitol is almost completely absorbed in the upper part of the small intestine, it has a long-lasting presence in the mucosa. It is not known whether this is relevant for comparative safety.

0 0

Post a comment