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- PPARy activation

Vascular effects

Endothelial cells macrophages VSMCs i Adhesion molecules Í MMPs t Plaque stability 4 Atherosclerosis Progression t Endothelial function

Metabolic effects

? Direct effects on

Adipose tissue

\ Lipolysis t Fat oxidation ©■ t Fat synthesis <J>"

\ Resistin t Adiponectin

Adipose tissue

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