Historical Perspective

With their eponymous paper of 1935, describing seven patients with polycystic ovaries (PCO), amenorrhea, hirsutism, and obesity, Stein and Leventhal are credited for defining the syndrome later to be known as PCOS (7), although others had reported case reports with similar ovarian pathology as early as 1721 (8-10). With a paper published in 1921, Achard and Thiers are considered to be the first to report on the association of hyperandrogenism and diabetes mellitus in a 71-year-old bearded obese woman (11). However, this disorder, which they called "diabete des femmes a barbe", was likely to be caused by adrenocortical pathology, rather than representative of PCOS. In 1980, with the development of standardized methods to measure insulin, Burghen et al. (12) demonstrated a correlation of hyperandrogenism with hyperinsulinemia in PCOS. With the first report on the amelioration of PCOS symptoms with the insulin sensitizer metformin by Velazquez et al. (13) in 1994, insulin resistance and its metabolic consequences have been established as an integral part of the syndrome (14).

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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