Historical Perspective

With their eponymous paper of 1935, describing seven patients with polycystic ovaries (PCO), amenorrhea, hirsutism, and obesity, Stein and Leventhal are credited for defining the syndrome later to be known as PCOS (7), although others had reported case reports with similar ovarian pathology as early as 1721 (8-10). With a paper published in 1921, Achard and Thiers are considered to be the first to report on the association of hyperandrogenism and diabetes mellitus in a 71-year-old bearded obese woman (11). However, this disorder, which they called "diabete des femmes a barbe", was likely to be caused by adrenocortical pathology, rather than representative of PCOS. In 1980, with the development of standardized methods to measure insulin, Burghen et al. (12) demonstrated a correlation of hyperandrogenism with hyperinsulinemia in PCOS. With the first report on the amelioration of PCOS symptoms with the insulin sensitizer metformin by Velazquez et al. (13) in 1994, insulin resistance and its metabolic consequences have been established as an integral part of the syndrome (14).

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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