Genetic Factors

The polygenic nature of the disease has it made difficult to dissect individual genes conferring increased risk for diabetes. In general, two methods, the so-called candidate gene approach and the genome-wide scan approach have been used. The candidate gene approach examines specific genes with a plausible role in the disease process. The genome-wide scan locates genes through their chromosomal (genomic) position. In genetic studies the population-attributable risk is often given; this is the percentage of a disease that would be eliminated if the genetic factor were removed from the population.

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