A commonly used antiretroviral agent is also known to cause hyperglycemia and diabetes (103). Incidence of didanosine-induced pancreatitis is much higher in elder patients than young (10% vs. 5%) (104). Some reports indicate reversible hyperglycemia and diabetes without any evidence of pancreatitis (105). Albrecht et al. (106) prospectively followed 12 patients who at the beginning of didanosine treatment had normal glucose tolerance; six developed IGT, which reverted to normal glucose tolerance on discontinuation of didanosine.
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