Diazoxide

It is considered an orphan drug and is available in liquid form for the treatment of insulinoma. Short-term use of this agent for the treatment of hypertension has been associated with hyperglycemia and hyperosmolar non-ketotic coma (38). Direct inhibition of insulin secretion may be the primary mechanism responsible for the hyperglycemia (39) Other possible mechanisms may include direct stimulation of hepatic glucose production, increased epinephrine secretion, decreased insulin sensitivity and increased insulin clearance (40).

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