Defects In The Incretin Effect In Type Diabetes

The incretin effect is absent or diminished in type 2 diabetes. GLP-1 still stimulates insulin secretion in type 2 diabetic patients at higher plasma concentrations, whereas GIP has lost most of its insulinotropic activity (27-29). The reason for the loss of the insulinotropic action of GIP has not completely been elucidated yet. Specific defects in GIP signaling and general secretory defects of the beta cell are most likely responsible. GLP-1 secretion as well as GLP-1 action is diminished in type 2 diabetes, but supraphysiological concentrations of GLP-1 by exogenous administration of GLP-1 can restore the defects in the incretin effect. The therapeutic potential of GLP-1 as a pharmacological tool for treating type 2 diabetes has been suggested in the 1990s (29,30). The insulinotropic effect of GLP-1 is only present under hyperglycemic conditions providing the possibility of glucose normalization without the risk of hypoglycemias (29,31). GLP-1 has further physiological actions that may be advantageous in type 2 diabetes therapy.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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